I-Cushing's Syndrome (I-Fragile Skin Syndrome) Ezinjeni

Umzimba wenja uwuhlelo oluyingqayizivele olunezinqubo eziningi ze-biochemical. Izinga lokuthuthuka ngokomzimba nangokwengqondo kwesilwane kuncike eqophelweni lazo. Isizinda se-hormonal sithinteka ngokusebenza kahle kwezitho zangaphakathi zokufihla. Futhi uma kwenzeka ukuphazamiseka kwe-endocrine, inja ingathola i-Cushing's syndrome.

Izimbangela zalesi sifo

I-Cushing's syndrome ezinjeni ingenye yezifo ezivame kakhulu ze-hormonal. Ngayo, kunokwakheka okukhulayo kwama-glucocorticoids akhiqizwa izindlala ze-adrenal. Ngokuvamile, izinja ezindala kuneminyaka engu-7 ubudala zihlushwa yi-syndrome, kodwa izinja ezincane nazo zingathinteka. Izimbangela eziyinhloko zalesi sifo yilezi:

1. Izimila ze-pituitary gland. Iyayeka ukukhiqiza ihomoni i-ACTH ngenani elifanele futhi ayikwazi ukulawula izinga le-cortisol egazini. Lolu hlobo lwe-skin syndrome olubuthakathaka lwenzeka kuma-85-90% ezinja. 

2. Izimila zezindlala ze-adrenal. Kulokhu, inani eleqile le-cortisol likhiqizwa lapho inja ingena ezimeni ezibucayi futhi yethuka kakhulu. Ukweqisa noma ukuntuleka kwe-cortisol kuyindlela eqondile yokuthuthukiswa kwama-pathologies angathi sína emzimbeni wesilwane. I-Pathology yezindlala ze-adrenal ivame kakhulu ezinjeni ezindala eminyakeni eyi-11-12. 

3. Ushintsho lwesibili (iatrogenic hyperadrenocorticism). Kwenzeka ngenxa yokwelashwa isikhathi eside kwe-allergies, i-dermatitis kanye nokuvuvukala okukhulu ngemithamo emikhulu yezidakamizwa ze-hormonal ezivela eqenjini le-glucocorticoid.

Indlela yokubona nokwelapha i-Cushing's syndrome

Lesi sifo siqala ngezimpawu ezicacile:

• ukuchama njalo, lapho inja ingakwazi ukubekezelela nokuchama ekhaya;
• ukoma okunamandla nokungapheli;
• ubuthakathaka, ukukhathala, ukunganaki, ukozela;
• ukwanda kwesifiso sokudla ngokudla ngisho nezinto ezingenakudliwa;
• ukuwohloka kwesisu ngenxa ye-muscle atrophy;
• ukulahlekelwa izinwele esiswini nasezinhlangothini;
• ukulahlekelwa isisindo noma ukuzuza isisindo ngokudla okujwayelekile;
• ukuntuleka kokuxhumanisa;
• ukuphazamiseka kwe-hormonal: ukumisa i-estrus kwabesifazane kanye ne-atrophy yamasende kwabesilisa;
• izinguquko ekuziphatheni: inja enothando iba novalo, nolaka.

Lesi sifo sicashile, njengoba sihambisana nezinkinga ezihlukahlukene: umfutho wegazi ophakeme, izifo zezinso ne-urinary tract, isifo sikashukela, i-osteoporosis, ukuphazamiseka kwezitho zokuzala. 

Izinhlobo ezinjengomalusi, i-dachshund, i-beagle, i-terrier, i-poodle, i-labrador, i-boxer isengozini yesifo sika-Cushing, ngakho-ke abanikazi badinga ukuhlolwa ngezikhathi ezithile ukuze bathole lesi sifo. Ngokuvamile, lesi sifo sidlula izinja zezinhlobo ezinkulu ezinesisindo esingaphezu kwama-20 kg. Ukuxilongwa kwenziwa udokotela wezilwane futhi kungase kuhlanganise ukuhlolwa ngokomzimba, ukuhlolwa kwegazi kwasemtholampilo kanye namakhemikhali ezinto eziphilayo, ukuhlaziya umchamo, ama-X ray, i-MRI yezindlala ze-pituitary kanye nezindlala ze-adrenal, i-ultrasound, nokuhlolwa kokuhlolwa ukuze kutholwe izinga le-cortisol egazini. Ukuze uthole ukwelashwa, udokotela wezilwane usebenzisa izindlela zezokwelapha nezokuhlinzwa:

1. Esimweni sokuqala, udokotela angase anikeze ukwelashwa kwezidakamizwa ukulawula amazinga e-cortisol. 

2. Esimweni sesibili, angase asuse eyodwa noma zombili izindlala ze-adrenal futhi abeke inja ekwelashweni kwama-hormone.

Ezimeni ezithuthukile, udokotela wezilwane angase anikeze ukwelashwa impilo yonke. Isibonakaliso sokululama kwesilwane esifuywayo ukuncipha kwesifiso sokudla kanye nokudla okujwayelekile kwamanzi. Uma ukwelashwa kungaqalwa ngesikhathi, inja ingase ife ngenxa yokukhathala. 

Ingabe umuntu angasithola isifo sikaCushing?

Isifo sikaCushing asikwazi ukudlula izinja namakati kuphela, kodwa futhi nabantu, kodwa akusona isifo esithathelwanayo. Ukubonakaliswa kwemitholampilo ye-syndrome ezinjeni nakubantu kufana kakhulu: kubantu, ukukhuluphala kwesisu kwenzeka, izinguquko zesikhumba kanye ne-muscle atrophy. Uma lesi sifo siqalwa, umuntu angalahlekelwa imisipha namathambo, abe nomfutho wegazi ophakeme, uhlobo lwesifo sikashukela sohlobo 2, futhi angenwe izifo ezingavamile. Ezinganeni nasebancane, lokhu kuwukuxilongwa okungajwayelekile.

Sihluke kanjani isifo sikaCushing emakati nasezinjeni?

Ngokungafani nezinja, i-Cushing's syndrome ayivamile kumakati. 

• Omunye umehluko ekubonakalisweni komtholampilo kwalesi sifo ukulawulwa kabi kwesifo sikashukela esinokumelana ne-insulin okunzima. Isikhumba siba mncane futhi sibuthakathaka, ikati lilahlekelwa isisindo ngokushesha. 

• Umehluko wesibili izinwele ezingakhuli ngemva kokugunda, impandla emsileni futhi ibunile. 

• Umehluko wesithathu kulesi sifo ukwakheka kwezibalo zesikhumba ezinja entanyeni nasezindlebeni, okungenzeki kumakati.

Indlela yokuvimbela izifo

Uhlobo lwe-iatrogenic lwe-Cushing's disease kuphela ezinjeni olungavinjelwa ngomthamo olinganiselwe wezidakamizwa ze-hormonal ekwelapheni. Kungakhathaliseki ukuthi kufanele unikeze ukwelashwa okunjalo ngokwakho - kufanele uphumelele zonke izivivinyo futhi uthintane nodokotela wezilwane. Kunoma yikuphi, abanikazi kufanele baqaphe isimo sejazi lenja, izinguquko esuthi, ukwanda kokoma nokulahlekelwa izinwele, futhi uma kuvela izimpawu, thintana nomtholampilo wezilwane. Zonke lezi zimpawu zizosiza ukukhomba lesi sifo ngesikhathi futhi ugcine isilwane esifuywayo siphilile futhi siphila iminyaka eminingana eyengeziwe.