Babesiosis ezinjeni: ukwelashwa

 Ukwelapha izinja eziphethwe i-babesiosis, kuye kwahlolwa inani elikhulu lemithi ehlukene ngemiphumela ehlukene. 

Kodwa-ke, okuphuma ku-diamidine okusetshenziselwa ukwelapha i-canine babesiosis (i-bernil, i-batryzin, i-verbiben, i-azidin, njll.) inokusebenza okubanzi okusebenzayo. Isithako esisebenzayo sale mithi i-diminazene aceturate. I-Azidine iqukethe i-100% yesithako esisebenzayo. I-Bernil ikhiqizwa ngendlela yama-granules, i-23,6 g yayo iqukethe i-10,5 g yento esebenzayo. I-Batrizin ikhiqizwa ngendlela yama-granules, i-10,5 g yayo iqukethe i-4,66 g yento esebenzayo. I-Veriben ikhiqizwa ngendlela yama-granules, i-2,36 g yayo iqukethe i-1,05 g yento esebenzayo. I-Azidine, i-bernil ne-batryzine iyingxenye yeqembu "B" ngokuphathelene nobuthi. Umthamo omkhulu obekezelelwe wezidakamizwa wamagundane ngu-40 mg / kg, onogwaja - 25-30 mg / kg, izinja, izinkomo namahhashi - 10 mg / kg. Izidakamizwa azinawo umphumela wokuqongelela, kepha ngemithamo ephezulu zibanga ubuthi, obonakala ngokuphazamiseka emsebenzini wesimiso sezinzwa esimaphakathi: ukuququda kwe-tonic, i-ataxia, futhi kwesinye isikhathi ukuhlanza. I-Veriben ingeyezinhlanganisela ezinobuthi obusesilinganisweni ezilwaneni ezinegazi elifudumele. Umuthi unqwabelana ikakhulukazi esibindini nasezinso, ngamanani amancane ebuchosheni futhi ukhishwa ikakhulukazi emchamweni. Isenzo sezidakamizwa sisekelwe ekuvinjweni kwe-aerobic glycolysis kanye ne-DNA synthesis ku-pathogenic protozoa, umphumela esakhiweni esihle kanye nomsebenzi wamangqamuzana olwelwesi lwamaseli. Izimuncagazi zokumelana ne-bernil ziyisici esinqumayo ekusindeni kwento ephilayo ngayinye. Okuphuma kwesibili kwe-diamidine, okusebenzayo kokubili ngokumelene no-B. i-canis, nezinye izinhlobo zezifo - i-pentamidine, isetshenziswa kumthamo we-16,5 mg / kg kabili ngesikhawu sansuku zonke. Ngokusetshenziswa kwayo, imiphumela emibi efana nobuhlungu endaweni yomjovo, i-tachycardia, isicanucanu nokuhlanza kungenzeka. Umuthi osebenza kahle kakhulu ngokumelene no-B. I-canis iyi-imidocarb (ephuma ku-carbanilide) esetshenziswa ngethamo lika-5 mg/kg. Ngokusho kwabanye ababhali, i-berynyl ne-azidine ibulala amagciwane emzimbeni wezilwane futhi ivimbela i-babesiosis lapho ilawulwa 5-10 ngisho nezinsuku eziyi-17 ngaphambi kokutheleleka. Ngokuka-D.A. I-Strashnova (1975), i-bernil ngethamo lika-7 mg/kg wesisindo somzimba ivimbela ukutheleleka kwezinja nge-pathogen B. canis zingakapheli izinsuku eziyi-15. Kodwa-ke, ukuphathwa kwe-berenyl ngezinhloso zokuvimbela kanye negazi elihlaselayo akuzange kubulale amagciwane emzimbeni wezinja kusuka ku-B. canis, kodwa, nokho, ukuphindaphindeka kwe-pathogen egazini kuncipha kakhulu. Ukuze unciphise umthelela we-pathological ngenxa yomsebenzi obalulekile wama-parasites nokufa kwawo okukhulu ngemva kokuphathwa kwezidakamizwa ezilwa nengane, kanye nokunciphisa imiphumela enobuthi yezidakamizwa ze-protistocidal, ukwelashwa okuhlukahlukene kwezimpawu kufanele kusetshenziswe. Ukuze kuthuthukiswe umsebenzi wenhliziyo, kusetshenziswa amalungiselelo ahlukahlukene enhliziyo. Ngokuvamile, i-sulfocamphocaine isetshenziswa ngendlela yesisombululo esingu-10% ngaphansi kwesikhumba noma nge-intramuscularly ngethamo lika-1,0 ml nge-20 kg yesisindo esiphilayo senja. Umuthi uphathwa izikhathi ezi-1-2 phakathi nayo yonke inkambo yokwelashwa. Amanye amakhambi enhliziyo (riboxin, cordiamin, camphor) nawo asetshenziswa. Ukudambisa ukudakwa okuvamile, isidakamizwa i-gamavit sisetshenziswa, esiqukethe ingxube elinganiselayo ye-physiologically yama-amino acid angama-20, amavithamini ayi-17, izingcezu ze-nucleic acid, izakhi zokulandelela, kanye ne-placental extract kanye ne-immunostimulant (i-sodium nucleinate). Izinkomba eziyinhloko zokusetshenziswa kwe-gamavit yizindawo zayo njenge-detoxicant, eqinisekisa ukungathathi hlangothi nokususwa kwemikhiqizo ebolile enobuthi, futhi ijwayele imisebenzi ephazamisekile ngenxa yokuchayeka kwayo. I-Gamavit inomthelela ekubuyiselweni komsebenzi we-hematopoietic okhubazekile ku-babesiosis. ₉) kanye ne-L-glutamic acid, ibandakanyeka ekugcineni i-hematopoiesis. Umuthi kufanele uphathwe ngaphansi kwesikhumba ngethamo lika-0,1 ml / kg wesisindo somzimba izinsuku ezingama-5-7. Imvamisa, i-edema yezingxenye ezahlukahlukene zomzimba ezinjeni kanye nokopha kulwelwesi lwamafinyila kunemvelaphi efanayo futhi kubangelwa ukwanda kwemithambo yegazi ngenxa yokuchayeka ebuthini. Ukubuyisela ubuqotho nokuvimbela ukwephulwa kwezindonga zemithambo yegazi, i-etamsylate (dicinone) isetshenziswa ngendlela yesixazululo esingu-12,5% nge-intramuscularly. Umuthi uphathwa ngethamo lika-1,0 ml nge-20 kg yesisindo somzimba kanye ngosuku ngezinsuku zokuqala ezingama-2-3 zokwelashwa. Izenzakalo ze-Meningeal ezibhaliswe kwezinye izinja kungenzeka ukuthi zibangelwa ukuthuthukiswa kwe-microflora engosomathuba ngenxa yokuncipha kokumelana kwesilwane esigulayo. Ngakho-ke, ukuvimbela ukuvela kwalesi sibonakaliso esiyinkimbinkimbi, kuyadingeka ukusebenzisa ama-antimicrobial agents. Ngokusekelwe kulokhu, imijovo ye-benzylpenicillin kasawoti we-sodium kufanele ifakwe ngesikhathi sokwelashwa kwe-babesiosis ukuvimbela imicimbi ye-meningeal ezinjeni. Umuthi uphathwa nge-intramuscularly ngomthamo wamayunithi ayizinkulungwane eziyi-10-15 ngekhilogremu ngayinye yesisindo somzimba njalo emahoreni ayi-6, kusukela kumthamo wokuqala wesilwane, phakathi nesikhathi sokwelashwa. Ama-antihistamine kanye ne-corticosteroids (i-dexamethasone, i-prednisolone) asetshenziselwa ukunciphisa ukusabela kokuvuvukala okuphelele. Kuyaziwa ukuthi ukusetshenziswa isikhathi eside kwe-corticosteroids kungabangela ukwephulwa kwe-water-sodium metabolism emzimbeni noma kuholele ekuvinjweni komsebenzi we-adrenal cortex. Ngakho-ke, ukuze ugweme lezi zenzakalo, ezinsukwini ezimbili zokugcina umuthi uphathwa ngemithamo encishisiwe. Ukugcina ukusebenza kwesibindi ezinjeni ezigulayo, i-Essentiale forte nayo isetshenziswa ngethamo lika-3-5 ml ngesilwane ngasinye nge-intravenously izinsuku ezingu-5-7.

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